CARDIAC NEXUS
Advanced Cardiac Signal Analysis Using Sheaf Theory & TDA
The Challenge
Modern cardiac mapping systems collect thousands of electrical signals during electrophysiology procedures, but existing tools analyze each signal independently. This fragmented approach loses critical information about the heart's global organizational principles and arrhythmia mechanisms.
Our Solution
CARDIAC NEXUS reimagines cardiac electrical data as a geometric object with intrinsic structure. By applying Sheaf Theory, Geometric Analysis, and Topological Data Analysis (TDA), we transform raw electrograms into a unified mathematical framework that reveals:
- Local Activation Times (LAT) as singularities in global coherence fields
- Conduction block detection through sheaf cohomology
- Rotor cores as topological defects where phase consistency breaks down
- Predictive identification of optimal ablation targets
Impact
Technologies
3D Patient-Specific Cardiac Solutions
Precision Surgical Guides & Multi-Modal Reconstruction
The Challenge
Cardiac ablation procedures require navigating complex 3D anatomy while performing delicate interventions. Traditional 2D imaging creates cognitive load, increases procedure time, and limits precision—particularly for challenging cases like Brugada syndrome and ventricular tachycardia ablation.
Our Innovation
We developed an integrated technological ecosystem combining:
- 3D-Printed Surgical Guides: Patient-specific biocompatible templates derived from pre-procedural imaging, showing optimal access trajectories and ablation targets
- Photogrammetric Reconstruction: Transforming 2D photographs into high-fidelity 3D models with sub-millimeter precision
- Universal Mapping Reconstruction: Digital reproduction of cardiac electrical mapping from any system (CARTO, EnSite, Rhythmia)
- Computational Simulations: Pre-procedural "rehearsal" with lesion prediction and outcome modeling
Clinical Impact
Technologies
AGH Platform
Digital Farm Management & Regulatory Compliance System
The Problem
Agricultural operations face overwhelming bureaucratic complexity with paper-based record-keeping, manual compliance tracking, and fragmented documentation—leading to lost deductions, regulatory penalties, and hours of wasted time.
The Solution
AGH Platform is a complete quaderno di campagna digitale providing:
- Field Management: Cadastral data, surfaces, crops with automatic PAC/PSR compliance validation
- Activity Logging: Digital registry for treatments, fertilization, seeding, harvests with automatic categorization
- Authorized Products Database: 17,000+ phytosanitary products always updated with ministerial register
- Traceability: Complete tracking from seed to sale with batch management
- Smart Analytics: Real-time compliance scores, trend analysis, and decision support
- Professional Reporting: One-click PDF/Excel generation for inspections and certifications
Business Impact
Technologies
Academic Admission Management System
Complete Application Tracking for International Programs
The Challenge
Universities receiving hundreds of international applications face document chaos, lost files, fragmented communications, and lack of real-time visibility—creating stress for both administrators and candidates.
The System
End-to-end candidate management platform featuring:
- Dual Storage Architecture: Innovative redundant system (Google Drive + MySQL LONGBLOB) ensuring zero data loss and 24/7 availability
- Candidate Portal: Self-service status tracking, document upload, and direct messaging with administration
- Admin Dashboard: Real-time analytics, filtering, Gantt timeline visualization, and bulk communications
- Automated Workflows: Email notifications, status updates, and deadline reminders
- Program Management: Support for PhD, Post-Doc, Observer programs with custom requirements
Results
Technologies
EnzyFuel Biofuel Cells
Glucose-Powered Implantable Medical Devices
The Vision
Modern implantable devices—pacemakers, neurostimulators, continuous glucose monitors—face a fundamental constraint: batteries die. This creates surgical burden (replacements every 5-10 years), infection risk, patient anxiety, and design limitations.
The Technology
EnzyFuel develops next-generation enzymatic glucose biofuel cells that harvest energy directly from physiological glucose levels:
- Buckypaper Electrodes: Carbon nanotube substrates providing high surface area (>1000 m²/g) and excellent conductivity
- GDH Functionalization: Glucose dehydrogenase covalently immobilized for selective glucose oxidation
- 3D-Printed Microfluidics: Custom channels mimicking capillary perfusion for optimal mass transport
- Oxygen-Independent: FAD-GDH eliminates oxygen dependency and toxic peroxide production
Performance Achieved
Market Opportunity
Target applications include continuous glucose monitors (CGM), cardiac pacemakers, and neurostimulators—addressing a $35B+ problem by eliminating 30-40% of revision surgeries. The technology enables perpetual self-powered implants using the body's own fuel.